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In a very life time carcinogenicity review carried out in B6C3F1 mice, methylphenidate induced a rise in hepatocellular adenomas, and in males only, an increase in hepatoblastomas in a day-to-day dose of about 60 mg/kg/working day. This dose is approximately two instances the MRHD of sixty mg/day presented to children on mg/m² foundation.RITALIN s